More than two dozen leading artificial intelligence companies have agreed to participate in the federal government’s “Genesis Mission,” a Trump administration initiative aimed at expanding the use of AI in scientific discovery and energy-related research.
Companies including OpenAI, Microsoft Corp., Nvidia Corp., Amazon Web Services and Alphabet Inc.’s Google are among those that have either signed memorandums of understanding with the federal government, already have projects with the US Department of Energy or its national laboratories, or have expressed interest in joining the effort, according to a White House statement released on Wednesday.
The Genesis Mission was announced last month by President Donald Trump through an executive order, with the stated goal of improving coordination across federal research agencies and accelerating scientific breakthroughs through the use of advanced AI tools.
Administration frames mission as long-term effort
Administration officials described the announcement of 24 research partnerships as an initial step rather than a final roster.
“Today’s announcement of 24 new research partnerships is only the beginning, as we deliver on President Trump’s mandate to bring the entire scientific community, including companies, universities, non-profits, and Federal agencies, into the Genesis Mission,” said Michael Kratsios, Assistant to the President and Director of the Office of Science and Technology Policy.
The participating organisations include Accenture, AMD, Anthropic, Armada, Amazon Web Services, Cerebras, CoreWeave, Dell, DrivenData, Google, Groq, Hewlett Packard Enterprise, IBM, Intel, Microsoft, Nvidia, OpenAI, Oracle, Periodic Labs, Palantir, Project Prometheus, Radical AI, xAI and XPRIZE.
Kratsios said the initiative is designed to integrate cutting-edge AI into the scientific process, allowing researchers to automate experiment design, accelerate simulations and generate predictive models.
“Harnessing cutting-edge AI for science will dramatically increase the productivity of American scientists and researchers,” Kratsios said.
He added that the mission could lead to breakthroughs in energy, manufacturing, drug discovery and other fields.
Role of national labs and federal data
The Genesis Mission is expected to rely heavily on the computing resources housed within the Energy Department’s national laboratories.
Kratsios previously said the initiative would use those facilities to tap into federal datasets and enable a greater volume of experiments that leverage AI.
Officials have argued that access to large-scale computing power will help shorten the timeline for discoveries by allowing researchers to run more simulations and explore complex scientific problems more efficiently.
At the same time, the administration has acknowledged that the expansion of AI research depends on energy-intensive data centres.
Officials have sought to pair the Genesis Mission with broader efforts to identify new energy sources and strengthen the power grid to support growing computational demand.
Balancing industry support and regulatory debate
President Trump has made fostering the domestic AI industry a priority since returning to office.
His administration has announced policies intended to ease the build-out of AI facilities and encourage the rapid development of new technologies.
Alongside those efforts, the White House has moved to curb certain state-level AI regulations, arguing that a patchwork of local rules could burden companies and slow innovation.
Critics of that approach have countered that state-based regulations are necessary to address near-term risks, including biased content, deepfakes and user safety concerns, particularly as federal rulemaking has progressed slowly.
The Energy Department said it expects to hold future convenings with private industry collaborators, academic institutions and philanthropic organizations to expand the pool of qualified participants.
The department is continuing to accept submissions under two open requests for information.
The “Partnerships for Transformational Artificial Intelligence Models” RFI will remain open until Jan. 14, 2026, while the “Transformational AI Capabilities for National Security” RFI is open until Jan. 23, 2026.
Officials said the Genesis Mission is intended to evolve over time as additional partners join and new research priorities emerge.
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